A dendrimer–hydrophobic interaction synergy improves the stability of polyion complex micelles

• DOI: 10.1039/c7py00304h
• Publication Date: 2017-03-28T18:00:59Z
• Authors: Marcos Fernandez-...; Ana Sousa-Herves; Silvia Porto; Noelia Guldris; José Martínez-Costas; Ricardo Riguera; Eduardo Fernandez...
• Keywords: Hydrophobic effect

Polyion complex (PIC) micelles incorporating PEG-dendritic copolymers display an unprecedented stability towards ionic strength that is amplified via hydrophobic interactions. The tridimensional orientation of peripheral linkers between charged groups and the globular/rigid dendritic scaffold maximizes this stabilization compared to PIC from linear polymers. As a result, stable at concentrations higher than 3 M NaCl are obtained, which represents highest saline concentration attained with micelles. Advantages stabilizing effect have been taken for design robust, pH-sensitive micelle controlled intracellular release anticancer drug doxorubicin. This displays slightly toxicity, distinctive mechanisms cell uptake trafficking relative free drug. preparation mixed by combining differently functionalized block has allowed fine-tuning their stability, paving way facile modulation properties like biodegradability, loading, or response external stimuli.