Alzheimer's amyloid-beta intermediates generated using polymer-nanodiscs

• DOI: 10.1039/c8cc07921h
• Publication Date: 2018-10-22T17:02:51Z
• Authors: Bikash R. Sahoo; Takuya Genjo; Michael Bekier; Sarah J. Cox; Andrea K. Stoddard; Magdalena Ivanova; Kazuma Yasuhara; Carol A. Fierke; Yanzhuang Wang; Ayyalusamy Ramamo...
• Keywords: 0301 basic medicine; Amyloid beta-Peptides; Cell Survival; Circular Dichroism; Dynamic Light Scattering; Peptide Fragments; Nanostructures; 3. Good health; Kinetics; 03 medical and health sciences; Microscopy, Fluorescence; Polymethacrylic Acids; Alzheimer Disease; Cell Line, Tumor; Humans; Thermodynamics; Dimyristoylphosphatidylcholine; Protein Binding

Polymethacrylate-copolymer (PMA) encased lipid-nanodiscs modulate Aβ1–40 aggregation and neurotoxicity.