A pH-driven ring translocation switch against cancer cells

• DOI: 10.1039/c8cc08681h
• Publication Date: 2018-11-15T09:10:02Z
• Authors: Qian Cheng; Hang Yin; Roselyne Rosas; Didier Gigmes; Olivier Ouari; Ruibing Wang; Anthony Kermagoret; David Bardelang
• Keywords: Bridged-Ring Compounds; Cell Survival; Imidazoles; Antineoplastic Agents; Hydrogen-Ion Concentration; 01 natural sciences; Viologens; 3. Good health; 0104 chemical sciences; Mice; RAW 264.7 Cells; Cell Line, Tumor; Neoplasms; [CHIM] Chemical Sciences; [CHIM]Chemical Sciences; Animals; Humans

A molecular switch built with cucurbit[7]uril and a 3-station viologen-phenylene-imidazole compound has showed pH actuated ring translocation with high fatigue resistance and promising features against cancer cells.