Ginnalin A from Kujin tea (Acer tataricum subsp. ginnala) exhibits a colorectal cancer chemoprevention effect via activation of the Nrf2/HO-1 signaling pathway

• DOI: 10.1039/c8fo00054a
• Publication Date: 2018-04-17T08:04:30Z
• Authors: Wu Bi; Chun-nian He; Xiao-xiao Li; Liu-ying Zhou; Rui-jie Liu; Sai Zhang; Guo-qing Li; Zhu-chu Chen; Peng-fei Zhang
• Keywords: 0301 basic medicine; NF-E2-Related Factor 2; Plant Extracts; Acer; Apoptosis; Cell Cycle Checkpoints; Deoxyglucose; Chemoprevention; 3. Good health; 03 medical and health sciences; Cell Line, Tumor; Gallic Acid; Humans; Colorectal Neoplasms; Heme Oxygenase-1; Signal Transduction

Ginnalin A may activate the Nrf2 signaling pathway through upregulation of p62 and inhibition Keap1 to exert a cancer chemoprevention effect.