A non-invasive nanoparticle mediated delivery of triamcinolone acetonide ameliorates diabetic retinopathy in rats

• DOI: 10.1039/c8nr00058a
• Publication Date: 2018-05-04T05:34:11Z
• Authors: Binapani Mahaling; Dadi A. Srinivasarao; G. Raghu; Rajesh K. Kasam; G. Bhanuprakash R...; Dhirendra S. Katti
• Keywords: Male; Vascular Endothelial Growth Factor A; 0301 basic medicine; Drug Carriers; Diabetic Retinopathy; Tumor Necrosis Factor-alpha; NF-kappa B; Poloxamer; Intercellular Adhesion Molecule-1; Triamcinolone Acetonide; Retina; Rats; 3. Good health; Rats, Sprague-Dawley; 03 medical and health sciences; Glial Fibrillary Acidic Protein; Animals; Humans; Nanoparticles; Ophthalmic Solutions; Neuroglia

A non-invasive, sustained release, polymeric nanoparticulate drug delivery system offers high retinal drug bioavailability so as to enable treatment of retinal complications effectively.