The effect of solution environment and the electrostatic factor on the crystallisation of desmotropes of irbesartan

• DOI: 10.1039/c8ra10146a
• Publication Date: 2019-02-11T16:52:49Z
• Authors: Andrea M. Araya-S...; Mariola Urgellés; Felipe Vásquez-Ca...; Felipe Vargas-Hue...; José Roberto Vega...; Teodolito Guillén...; Mirtha Navarro-Hoyos; Silvia L. Cuffini
• Keywords: Irbesartan; Tetrazole; Imidazole

The experimental conditions necessary for stabilising irbesartan (IBS) tautomers in solution and selectively obtaining the desmotropic crystal forms are presented herein. 1H 2H were stabilized specific 2H-tetrazole⋯imidazole interaction was confirmed by solution-state NMR. results showed that highly polar polarisable solvents (higher values of electrostatic factor (EF)) lead to crystallisation IBS form B. Furthermore, variations pH methanol, turn, determined desmotropes A and/or