A synthetic transcription factor pair mimic for precise recruitment of an epigenetic modifier to the targeted DNA locus

• DOI: 10.1039/c9cc09608f
• Publication Date: 2020-01-15T01:23:30Z
• Authors: Zutao Yu; Mengting Ai; Soumen K. Samanta; Fumitaka Hashiya; Junichi Taniguchi; Sefan Asamitsu; Shuji Ikeda; Kaori Hashiya; Toshikazu Bando; Ganesh N. Pandian; Lyle Isaacs; Hiroshi Sugiyama
• Keywords: Bridged-Ring Compounds; 0301 basic medicine; 03 medical and health sciences; Molecular Structure; Imidazoles; DNA; Epigenesis, Genetic; Transcription Factors

ePIP–HoGu not only mimics the transcription factor operation as pairs but is also capable of recruiting the epigenetic modifiers to a particular DNA locus.