Reduction of serum cholesterol and its mechanism byLactobacillus plantarumH6 screened from local fermented food products

• DOI: 10.1039/c9fo02478f
• Publication Date: 2020-01-14T11:43:37Z
• Authors: Tianming Qu; Liu Yang; Yuhua Wang; Bin Jiang; Minghao Shen; Dayong Ren
• Keywords: 2. Zero hunger; 0301 basic medicine; Anticholesteremic Agents; Hypercholesterolemia; 3. Good health; Mice, Inbred C57BL; Disease Models, Animal; Mice; 03 medical and health sciences; Cholesterol; Animals; Fermented Foods; Lactobacillus plantarum

Hypercholesterolemia is the leading cause of cardiovascular disease worldwide. In this study, lactic acid bacteria (Lactobacillus plantarum H6) screened from homemade fermented foods in northeastern China were used to study their cholesterol-lowering ability and analyze degradation mechanism. Results showed that L. H6 significantly reduced serum cholesterol levels C57BL/6 mice fed a hypercholesterolemia diet. It mainly promoted expression CYP7A1 gene by inhibiting farnesoid X receptor pathway increase vivo synthesis bile acids improved intestinal microbial community structure abundance bacterial flora containing salt hydrolase activity. Hence, played role reducing content mice.