Ce6/Mn2+-chelated polydopamine@black-TiO2 nanoprobes for enhanced synergistic phototherapy and magnetic resonance imaging in 4T1 breast cancer

• DOI: 10.1039/c9nr09236f
• Publication Date: 2019-12-12T03:03:45Z
• Authors: Yang Gao; Luyun Zhang; Yanhong Liu; Sijia Sun; Zhibin Yin; Lili Zhang; Aiguo Li; Guangming Lu; Aiguo Wu; Leyong Zeng
• Keywords: Nanoprobe

Black titanium dioxide (TiO2) nanoparticles have attracted great attention due to their application in photothermal therapy (PTT). However, single-mode phototherapy has the risk of recurrence, and high-dose laser usually imposed improve PTT performance can bring a potential threat security. Here, polydopamine (PDA)-coated black TiO2 (b-P25@PDA) with core-shell structure were synthesized for enhanced PTT; then, synergistic nanoprobes (b-P25@PDA-Ce6 (Mn)) constructed by coupling chlorin e6 (Ce6) chelating Mn2+ simultaneous photodynamic (PDT)/PTT magnetic resonance (MR) imaging, which low-dose was used imaging-guided high efficiency safety achieved. The prepared showed conversion (32.12%), reactive oxygen generation excellent MR imaging. In 4T1 tumor-bearing nude mouse model, tumors completely disappeared under combination PDT/PTT but only partially inhibited single PDT PTT. current work developed multifunctional TiO2-based nanoprobe will be important safe efficient visualized theranostics cancers.