Ene reactions of 2-borylated α-methylstyrenes: a practical route to 4-methylenechromanes and derivatives

• DOI: 10.1039/c9ob00963a
• Publication Date: 2019-05-17T15:34:47Z
• Authors: Chaima Boureghda; Aurélie Macé; Fabienne Berrée; Thierry Roisnel; Abdelmadjid Debache; Bertrand Carboni
• Keywords: Trifluoromethanesulfonate; Ene reaction; Scandium

4-Methylenechromanes were prepared <italic>via</italic> a three-step process from 2-borylated α-methylstyrenes using glyoxylate-ene reaction catalyzed by scandium(<sc>iii</sc>) triflate and Mitsunobu cyclization as key steps.