How bulky ligands control the chemoselectivity of Pd-catalyzed N-arylation of ammonia

• DOI: 10.1039/c9sc03095f
• Publication Date: 2019-12-12T14:03:40Z
• Authors: Seoung-Tae Kim; Suyeon Kim; Mu-Hyun Baik
• Keywords: Chemistry; 01 natural sciences; 0104 chemical sciences

Steric bulk has been recognized as a central design principle for ligands in the widely utilized Buchwald–Hartwig amination. This mechanistic study reveals how this steric effect manipulates the reaction pathway and determines the chemoselectivity.