ThX – a next-generation probe for the early detection of amyloid aggregates

• DOI: 10.1039/c9sc04730a
• Publication Date: 2020-02-21T08:13:40Z
• Authors: Lisa-Maria Needham; Judith Weber; Juan A. Varela; James W. B. Fyfe; Dung T. Do; Catherine K. Xu; Luke Tutton; Rachel Cliffe; Benjamin Keenlyside; David Klenerman; Christopher M. Do...; Christopher A. Hu...; Karin H. Müller; Kevin O'Holleran; Sarah E. Bohndiek; Thomas N. Snaddon; Steven F. Lee
• Keywords: 0301 basic medicine; Aging; 1.1 Normal biological development and functioning; Bioengineering; Neurodegenerative; Alzheimer's Disease; 03 medical and health sciences; Acquired Cognitive Impairment; QD; 34 Chemical Sciences; FOS: Clinical medicine; Neurosciences; 500; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); DAS; General Chemistry; 540; QD Chemistry; Brain Disorders; Chemistry; Neurological; Dementia; Generic health relevance; Biotechnology

Introducing ThX, a next-generation ThT derivative that allows for the early detection of amyloid aggregates at the bulk and single-aggregate levels.