An NIR-responsive mesoporous silica nanosystem for synergetic photothermal-immunoenhancement therapy of hepatocellular carcinoma

• DOI: 10.1039/c9tb01891c
• Publication Date: 2019-11-19T01:43:41Z
• Authors: Han Yang; Hong-sheng Liu; Wen Hou; Jun-xiao Gao; Yue Duan; Daohe Wei; Xiao-qun Gong; Han-jie Wang; Xiao-li Wu; Jin Chang
• Keywords: Indocyanine Green; 0303 health sciences; Carcinoma, Hepatocellular; Liver Neoplasms; Antineoplastic Agents; Phototherapy; Sorafenib; Silicon Dioxide; Theranostic Nanomedicine; 3. Good health; Mice, Inbred C57BL; Mice; 03 medical and health sciences; Cell Line, Tumor; Animals; Nanoparticles; Female; Immunotherapy

To create a more precise, efficient imaging and therapeutic strategy is big challenge for the current treatment of hepatocellular carcinoma (HCC). Photothermal therapy (PTT) has attracted enormous attention due to its non-invasive property precise spatial temporal control. Here, we developed realize superior performance treatment, utilizing an indocyanine green (ICG) sorafenib (S) co-loaded mesoporous silica nanosystem synergetic PTT/immuno-enhanced therapy. We proved that (ICG+S)@mSiO2 could be easily endocytosed by H22 cells, carried out outstanding real-time fluorescence imaging, enhanced cytotoxicity abilities near-infrared radiation (NIR) in vitro. Moreover, also had excellent ability, displayed remarkable photothermal tumor killing effect immune enhancement capability under 808 nm irradiation tumor-bearing mice model, without apparent adverse effects other organs. This study provides new development synergistic theranostic HCC.