STAT3/IL-6 dependent induction of inflammatory response in osteoblast and osteoclast formation in nanoscale wear particle-induced aseptic prosthesis loosening

• DOI: 10.1039/d0bm01256d
• Publication Date: 2020-12-10T21:41:39Z
• Authors: Zhantao Deng; Ruiying Zhang; Mengyuan Li; Shuai Wang; Guangtao Fu; Jiewen Jin; Zhenheng Wang; Yuanchen Ma; Qiujian Zheng
• Keywords: Osteolysis; Abrasion (mechanical); Inflammatory response

Our study demonstrated wear particles, which are generated by the abrasion of implanted prostheses, could induced STAT3 activation in osteoblasts. And further, inflammatory responses and RANKL expression would activate osteoclasts cause osteolysis.