Polymyxin-based photosensitizer for the potent and selective killing of Gram-negative bacteria

• DOI: 10.1039/d0cc00155d
• Publication Date: 2020-02-26T12:06:56Z
• Authors: Muhammed Ucuncu; Bethany Mills; Sheelagh Duncan; Matteo Staderini; Kevin Dhaliwal; Mark Bradley
• Keywords: Polymyxin; Phototoxicity; Gram-Negative Bacteria; Polymyxin B; Methylene blue; Conjugate

The methylene blue-polymyxin conjugate demonstrated high selectivity, sensitivity and phototoxicity against Gram-negative bacteria, including in early biofilm models.