Rh(iii)-catalyzed spiroannulation of 3-arylquinoxalin-2(1H)-ones with alkynes: practical access to spiroquinoxalinones

• DOI: 10.1039/d0ra03348k
• Publication Date: 2020-06-10T11:12:57Z
• Authors: Yuanfei Zhang; Ting Huang; Xinghua Li; Min Zhang; Ying Song; Kelin Huang; Weiping Su
• Keywords: Annulation; Surface Modification; Sequence (biology)

The Rh(iii)-catalyzed synthesis of spiroquinoxalinone derivatives from 3-arylquinoxalin-2(1H)-ones and alkynes via a C-H functionalization/[3 + 2] annulation sequence has been developed. This method, featuring low catalyst loading, was amenable to Gram scale tolerated variety functional groups substitution patterns on the aryl rings, providing target products in good excellent yields.