Targeting self-assembled F127-peptide polymer with pH sensitivity for release of anticancer drugs

• DOI: 10.1039/d0ra09898a
• Publication Date: 2021-01-05T12:29:37Z
• Authors: Wenzhao Han; Fanwei Meng; Hao Gan; Feng Guo; Junfeng Ke; Liping Wang
• Keywords: Cardiotoxicity

The treatment of breast cancer mainly relies on chemotherapy drugs, which present significant side effects. most typical example is the cardiotoxicity and bone marrow suppression associated with doxorubicin (DOX). Therefore, this drug not first choice in clinical treatment. We designed ATN-FFPFF-ATN, a new targeted antitumor carrier, polymerized from phenylalanine dipeptide (FF), ATN-161 peptide, Pluronic® F-127. peptide F-127 are linked acetal are, therefore, acid-sensitive. As can reduce pH through complex mechanisms subsequently maintain acid ambience, our vehicle smartly unravel at peculiar position, specifically accumulate inside tumor. protein ligand integrin α5β1, highly expressed surface some cells. This targeting sequence play role selective delivery DOX to tumor DOX-carrying vector was able significantly inhibit cell proliferation promote apoptosis MDA-MB-231 Based these results, ATN-FFPFF-ATN response promising for delivery.