Metabolic mechanisms of a drug revealed by distortion-free 13C tracer analysis

• DOI: 10.1039/d0sc06480g
• Publication Date: 2021-02-24T09:17:14Z
• Authors: Jin Wook Cha; Xing Jin; Sihyang Jo; Yong Jin An; Sunghyouk Park
• Keywords: 0301 basic medicine; Chemistry; 03 medical and health sciences

Our approach provides high-resolution and distortion-free NMR for metabolic tracer analysis. It confirmed the conventional mechanism of dichloroacetate and suggested a new one involving an enhanced contribution of PPP to cytosolic serine synthesis.