Screening and identification of a novel antidiabetic peptide from collagen hydrolysates of Chinese giant salamander skin: network pharmacology, inhibition kinetics and protection of IR-HepG2 cells

• DOI: 10.1039/d1fo03527d
• Publication Date: 2022-02-14T11:36:03Z
• Authors: Ming Zhou; Guoyan Ren; Bin Zhang; Fuli Ma; Jinling Fan; Zhijun Qiu
• Keywords: Protein Hydrolysates; Superoxide Dismutase; Urodela; Hep G2 Cells; 04 agricultural and veterinary sciences; Network Pharmacology; Peptide Fragments; 3. Good health; Molecular Docking Simulation; Kinetics; Oxidative Stress; Glucose; 0404 agricultural biotechnology; Diabetes Mellitus, Type 2; Malondialdehyde; Animals; Humans; Hypoglycemic Agents; Glycoside Hydrolase Inhibitors; Collagen; Insulin Resistance; Glycogen; Skin

A new antidiabetic peptide was screened from the collagen hydrolysates of Andrias davidianus skin by the network pharmacology method, and its glucose-lowering activity was detected by α-glycosidase inhibition assay and cell assay.