Design of carboxylated single-walled carbon nanotubes as highly efficient inhibitors against Aβ40 fibrillation based on the HyBER mechanism

• DOI: 10.1039/d1tb00920f
• Publication Date: 2021-08-03T01:24:23Z
• Authors: Wenping Zhao; Luying Jiang; Wenjuan Wang; Jingcheng Sang; Quancheng Sun; Qinchen Dong; Li Li; Fuping Lu; Fufeng Liu
• Keywords: 0301 basic medicine; Amyloid beta-Peptides; Cell Survival; Nanotubes, Carbon; Static Electricity; Biocompatible Materials; Molecular Dynamics Simulation; PC12 Cells; Rats; 3. Good health; Protein Aggregates; 03 medical and health sciences; Neuroprotective Agents; Alzheimer Disease; Materials Testing; Animals; Particle Size; Hydrophobic and Hydrophilic Interactions

SWCNT-COOH designed based on the HyBER mechanism can effectively inhibit Aβ fibrillization. SWCNT-COOH with more carboxyl groups can depolymerize mature Aβ fibrils into amorphous species with low toxicity.