A polymeric IDO inhibitor based on poly(ethylene glycol)-b-poly(l-tyrosine-co-1-methyl-d-tryptophan) enables facile trident cancer immunotherapy

• DOI: 10.1039/d2bm01181f
• Publication Date: 2022-08-30T10:48:52Z
• Authors: Yuanyuan Liu; Jiguo Xie; Xiaofei Zhao; Yueyue Zhang; Zhiyuan Zhong; Chao Deng
• Keywords: 0301 basic medicine; Polymers; Tumor Necrosis Factor-alpha; Tryptophan; CD8-Positive T-Lymphocytes; B7-H1 Antigen; Chromatin; Polyethylene Glycols; 3. Good health; Mice, Inbred C57BL; Interferon-gamma; Mice; 03 medical and health sciences; Doxorubicin; Animals; Indoleamine-Pyrrole 2,3,-Dioxygenase; Polystyrenes; Tyrosine; Immunotherapy; Enzyme Inhibitors; Kynurenine

A polymeric IDO inhibitor has been developed for the first time from copolypeptides for facile trident cancer immunotherapy.