Fibroblast-targeting polymeric nanovehicles to enhance topical wound healing through promotion of PAR-2 receptor-mediated endocytosis

• DOI: 10.1039/d2bm01357f
• Publication Date: 2022-11-22T16:01:32Z
• Authors: Yousong Lee; Seulgi Kim; Jihye Seo; Hyo Keun Kim; Yeong Pin Han; Eun Ju Park; Jin Oh Park; Chul-Su Yang; Jin Woong Kim
• Keywords: Dermal fibroblast

The level of collagen production critically determines skin wound contraction. If an intelligent drug delivery technology that enables in a specific area is developed, breakthrough healing treatment would be expected. However, such has not yet been developed as much the field anticancer therapy. In this study, we propose smart system using polymeric nanovehicles (PNVs), which periphery conjugated with fibroblast-targeting collagen-derived peptide, KTTKS (Lys-Thr-Thr-Lys-Ser). We showed surface engineering PNVs simultaneous PEGylation and peptide patching improved dispersibility PNVs, while promoting selective cellular uptake to fibroblasts via PAR-2 receptor-mediated endocytosis. vitro vivo assays revealed curcumin-loaded significantly enhanced activities, thus promising effective tissue regeneration.