Pre-targeting of polymeric nanomaterials to balance tumour accumulation and clearance

• DOI: 10.1039/d2cc02443h
• Publication Date: 2022-06-21T12:25:22Z
• Authors: N. L. Fletcher; A. Prior; O. Choy; J. Humphries; P. Huda; S. Ghosh; Z. H. Houston; C. A. Bell; K. J. Thurecht
• Keywords: Nanomaterials

Pre-targeting of bispecific antibodies is probed to enhance tumour retention while limiting clearance administered multifunctional branched PEGylated nanomedicines. The temporal influence pre-targeting on polymer interaction with cells and tissue explored using in vitro assays through preclinical validation.