Transition metal-free approach for late-stage benzylic C(sp3)–H etherifications and esterifications

• DOI: 10.1039/d2cc02661a
• Publication Date: 2022-09-05T08:02:01Z
• Authors: Yu Zhang; Prakash Kumar Sahoo; Peng Ren; Yuman Qin; Robin Cauwenbergh; Philippe Nimmegeers; Gandhi SivaRaman; Steven Van Passel; Andrea Guidetti; Shoubhik Das
• Keywords: Surface Modification

We report a transition metal-free approach for the regioselective functionalization of benzylic C(sp3)-H bonds using alcohols and carboxylic acids as nucleophiles. This straightforward general route has provided various ethers esters, including twelve pharmaceutically relevant compounds.