Oxidative carbonylation of N-protected indoles by Rh(iii)-zeolites

• DOI: 10.1039/d2cc05953c
• Publication Date: 2023-02-03T08:01:42Z
• Authors: Sam Van Minnebruggen; Carlos Marquez; Besir Krasniqi; Kwinten Janssens; Niels Van Velthoven; Jannick Vercammen; Benoit De Soete; Aram Bugaev; Dirk De Vos
• Keywords: Carbonylation; X-ray absorption spectroscopy

The oxidative carbonylation of N-protected indoles was investigated to directly synthesize indole-3-carboxylic acids. Using Rh(III)-zeolites as heterogeneous catalysts, the single-site Rh-species reach unprecedented activities (>100 turnovers), while metal is readily recovered after reaction. X-ray absorption spectroscopy (XAS) provided evidence for site-isolation Rh(III) species on zeolite.