Photoreductive β-aminoalkylation with amino acids affords functionalized γ-aminoketones for nucleoside mimics

• DOI: 10.1039/d2cc06071j
• Publication Date: 2023-01-23T10:40:57Z
• Authors: Sebastian O. Klein; Adina A. Baniahmad; Manfred Jung
• Keywords: Nucleosides; Amino Acids; Carbasugars; Amines; 540; 01 natural sciences; 0104 chemical sciences

We developed a facile photoreductive and stereoselective β-aminoalkylation of crowded enone by blue LED light irradiation using wide variety α-amino acids in order to access 5'-amino substituted carbasugar nucleosides for SAM-based methyltransferase inhibitors. This photochemical method provides highly functionalized mimics nucleoside analogue synthesis.