Functional insight into Cordyceps militaris sugar transporters by structure modeling, network analysis and allosteric regulation

• DOI: 10.1039/d2cp05611a
• Publication Date: 2023-05-09T06:21:11Z
• Authors: Xin Liu; Hanyang Zhang; Ziyun Zhou; Pranesha Prabhakaran; Wanwipa Vongsangnak; Guang Hu; Fei Xiao
• Keywords: Allosteric Regulation; Cordyceps; Amino Acid Sequence; Sugars; Phylogeny

Structure, network modeling and dynamic spectrum of C. militaris sugar transporters were investigated. An allosteric site (H1 region) which guided allosteric pathways between this region and the channel cavity was identified in the Hex subfamily.