Mixed nuts with high nutrient density improve insulin resistance in mice by gut microbiota remodeling

• DOI: 10.1039/d2fo01479c
• Publication Date: 2022-08-29T06:21:18Z
• Authors: Xinyue Li; Youjiao Wang; Jingbo Zhou; Zhongya Wang; Yiying Wang; Jie Zheng; Mei Sun; Long Jin; Ce Qi; Jin Sun
• Keywords: Male; 0301 basic medicine; Nutrients; Diet, High-Fat; Gastrointestinal Microbiome; Mice, Inbred C57BL; Mice; 03 medical and health sciences; C-Reactive Protein; Cholesterol; Ellagic Acid; Animals; Nuts; Insulin Resistance

The consumption of mixed nuts is a healthy dietary strategy to reduce the risk cardiovascular disease and has prebiotic effect on gut microbiota. However, there lack basic research based nut formulation. This study established new method for optimizing formulations using Nutrient Rich Food (NRF) index model. indices were adjusted by combining 10 8 encouraging nutrients 3 limiting dried fruits, respectively. optimized formulation had highest total NRF lowest energy, which was achieved applying linear programming. an insulin resistance microbiota investigated in animal model metabolic disorders caused high-fat diet. Male C57BL/6J mice (n = 12 per group) fed low-fat diet, diet (HFD), HFD with supplemented classical randomized controlled trial formula (MN1), commercially available (MN2), high-nutrient density (MN3), or ellagic acid (positive control). MN3 treatment decreased plasma cholesterol, homeostasis assessment-insulin index, high sensitivity C-reactive protein, zonulin levels, strengthened intestinal barrier, significantly altered β-diversity as compared group. These effects superior MN1 MN2. In conclusion, nutrient improved low-grade inflammation via remodeling.