Inhibition of Ca2+-calpain signaling is a new mechanism using Laminaria japonica polysaccharide to prevent macrophage foam cell formation and atherosclerosis

• DOI: 10.1039/d2fo04099a
• Publication Date: 2023-04-17T13:50:34Z
• Authors: Xue-Ying Li; Dan-Dan Kuang; An-Jun Guo; Yuan-Yuan Deng; Li-Hua Pan; Qiang-Ming Li; Jian-Ping Luo; Xue-Qiang Zha
• Keywords: Foam cell; Fucoidan

The LJP61A suppressed macrophage foam cell formation and atherosclerotic progression by modulating Ca 2+ -calpain mediated autophagy inhibition.