Amorphous ferric oxide-coating selenium core–shell nanoparticles: a self-preservation Pt(iv) platform for multi-modal cancer therapies through hydrogen peroxide depletion-mediated anti-angiogenesis, apoptosis and ferroptosis

• DOI: 10.1039/d2nr01837c
• Publication Date: 2022-07-12T02:21:36Z
• Authors: Zhaowei Xu; Qingdong Li; Caiyun Zhang; Peng Wang; Xiaotong Xu; Lang Ran; Li Zhang; Geng Tian; Guilong Zhang
• Keywords: Vascular Endothelial Growth Factor A; Apoptosis; Hydrogen Peroxide; Ferric Compounds; 3. Good health; Selenium; 03 medical and health sciences; 0302 clinical medicine; Cell Line, Tumor; Neoplasms; Tumor Microenvironment; Ferroptosis; Humans; Nanoparticles; Prodrugs; Reactive Oxygen Species

A synergistic action mechanism of iAIO@NSe-Pt suppressed tumor growth via hydrogen peroxide depletion-mediated anti-angiogenesis, apoptosis and ferroptosis.