Metal binding and interdomain thermodynamics of mammalian metallothionein-3: enthalpically favoured Cu+supplants entropically favoured Zn2+to form Cu4+clusters under physiological conditions

• DOI: 10.1039/d2sc00676f
• Publication Date: 2022-04-04T10:02:32Z
• Authors: Matthew R. Mehlen...; Rahma Elsiesy; Rabina Lakha; Rhiza Lyne E. Vil...; Marina Orman; Christina L. Vizc...; Gabriele Meloni; Dean E. Wilcox; Rachel N. Austin
• Keywords: 0301 basic medicine; Chemistry; 03 medical and health sciences

Metallothioneins (MTs) are a ubiquitous class of small metal-binding proteins involved in metal homeostasis and detoxification.