Tumor-derived microvesicles for cancer therapy

• DOI: 10.1039/d3bm01980b
• Publication Date: 2024-01-25T00:01:11Z
• Authors: Shiqi Yang; Bo Zheng; Faisal Raza; Shulei Zhang; Wei-en Yuan; Jing Su; Mingfeng Qiu
• Keywords: Cancer Therapy

Extracellular vesicles (EVs) are with lipid bilayer structures shed from the plasma membrane of cells. Microvesicles (MVs) a subset EVs containing proteins, lipids, nucleic acids, and other metabolites. MVs can be produced under specific cell stimulation conditions isolated by modern separation technology. Due to their tumor homing large volume, cell-derived microvesicles (TMVs) have attracted interest recently become excellent delivery carriers for therapeutic vaccines, imaging agents or antitumor drugs. However, preparing sufficient high-purity TMVs conducting clinical transformation has challenge in this field. In review, recent research achievements generation, isolation, characterization, modification, application cancer therapy reviewed, challenges facing applications also highlighted.