Thiochromenocarbazole imide-based photosensitizers decorated with carbonic anhydrase inhibitors for the targeted treatment of hypoxic tumours

• DOI: 10.1039/d3ma00926b
• Publication Date: 2024-02-21T09:21:01Z
• Authors: Amina Merabti; Darío Puchán Sánchez; Alessio Nocentini; Lamiaa M. A. Ali; Christophe Nguyen; Denis Durand; Kathleen Hamon; Tatiana Ghanem; Philippe Arnoux; Pierre Josse; Céline Frochot; Raivis Zalubovskis; Sébastien Richeter; Magali Gary-Bobo; Claudiu T. Supuran; Clément Cabanetos; Jean-Yves Winum; Sébastien Clément
• Keywords: Imide

A series of thiochromenocarbazole imide (TCI) photosensitizers featuring carbonic anhydrase inhibitors (CAi) was designed to alleviate the consequences PDT-induced hypoxia by merging advantages hCA IX knockdowns with PDT.