Modular synthesis of functional libraries by accelerated SuFEx click chemistry

• DOI: 10.1039/d3sc05729a
• Publication Date: 2024-03-04T11:44:01Z
• Authors: Joshua A. Homer; Rebecca A. Koelln; Andrew S. Barrow; Timothy L. Gialelis; Zlata Boiarska; Nikita S. Steinohrt; Erinna F. Lee; Wen-Hsuan Yang; Robert M. Johnson; Taemoon Chung; Amber N. Habowski; Dharmendra S. Vis...; Debmalya Bhunia; Charlotte Avanzi; Adam D. Moorhouse; Mary Jackson; David A. Tuveson; Scott K. Lyons; Michael J. Lukey; W. Douglas Fairlie; Shozeb M. Haider; Michel O. Steinmetz; Andrea E. Prota; John E. Moses
• Keywords: Chemistry; Accelerated SuFEx Click Chemistry; Chemical sciences; FOS: Chemical sciences; click chemistry; Medicinal and biomolecular chemistry; Organic chemistry; chemistry; techniques; 01 natural sciences; 0104 chemical sciences

The Accelerated SuFEx Click Chemistry (ASCC) protocol, adapted to a 96-well plate format, has been applied the late-stage derivatization of bioactive molecules and array synthesis anticancer agents, showcasing its potential for drug discovery.