Pericardial bioscaffold coated with ECM gels and urothelial cells for the repair of a rabbit urinary bladder defect

• DOI: 10.1039/d4bm00846d
• Publication Date: 2024-12-03T13:40:48Z
• Authors: Guadalupe H. Luev...; Rosalinda Rocha-J...; Juan Vargas-Mancilla; Jorge M. Flores-M...; Francisco J. Rojo; Gustavo V. Guinea; Birzabith Mendoza...
• Keywords: Rabbit (cipher)

Repair of damaged or faulty complex modular organs such as the urinary bladder is a current clinical challenge. The design constructs for reconstructive urological surgery can draw advantage from bioactivity natural extracellular matrix (ECM) bioscaffolds, well activity provided by cells seeded into constructs. Considering these benefits, this work compares performance pericardial ECM bioscaffolds and with gel-supported urothelial in repair defects rabbits. considered study are porcine (pM) bovine (bM) origin exhibited residual composition that confers mesh presentation. Coating an gel on promoted adhesion viability cells. Repairing full-thickness defect rabbit model resulted integration host bladder; meanwhile, volumetric capacity was using bM Although no contribution gel/cell seeding to failure mechanical properties neobladder observed, technique suitable different strategies engineer surgery.