Exploring medium and long arm extensions of 1,2,4-triazole derivatives as Candida albicans 14α-demethylase (CYP51) inhibitors

• DOI: 10.1039/d4md00863d
• Publication Date: 2025-03-12T13:20:47Z
• Authors: Marwa Alsulaimany; Faizah A. Binjubair; Esra Tatar; Diane E. Kelly; Steven L. Kelly; Andrew G. Warrilow; Mikhail V. Keniya; Brian C. Monk; Josie E. Parker; Claire Simons

1,2,4-trizole derivatives were designed to study their inhibition of Candida albicans CYP51 (IC50), binding affinity (Kd) and antifungal profile vs. wild-type and resistant model fungal strains comparable with posaconazole.