Design and interaction mechanism of novel SIRT1 inhibitors for the treatment of hepatocellular carcinoma

• DOI: 10.1039/d4nj04822a
• Publication Date: 2025-03-20T18:00:33Z
• Authors: Jing Luo; Xiaomeng Wang; Qiao Fu; Yan Yang; Zhenxing Yu; Juan Wang

Silent information regulator sirtuin 1 (SIRT1) is a niacinamide adenine dinucleotide (NAD)-dependent histone deacetylase and a promising target for the treatment of hepatocellular carcinoma (HCC).