Synthesis of novel phthalazine-based derivatives with potent cytotoxicity against HCT-116 cells through apoptosis and VEGFR2 inhibition

• DOI: 10.1039/d4ra02103g
• Publication Date: 2024-04-24T08:14:47Z
• Authors: Donia El Sayed; Samir M. El Rayes; Hamdy A. Soliman; Imad Eddin AlBalaa; Mansour S. Alturki; Abdulaziz Hassan ...; Mohammed Abdullah...; Mohamed S. Nafie
• Keywords: Chemistry; 01 natural sciences; 0104 chemical sciences

A novel phthalazine derivative exhibited potent cytotoxicity against HCT-116 cells as VEGFR2 inhibitor and apoptosis cell death.