Targeting EGFR/PI3K/AKT/mTOR signaling in lung and colon cancers: synthesis, antitumor evaluation of new 1,2,4-oxdiazoles tethered 1,2,3-triazoles

• DOI: 10.1039/d4ra02222j
• Publication Date: 2024-05-22T13:34:55Z
• Authors: Mohammed Salah Ayoup; Islam Shawki; Hamida Abdel-Hamid; Doaa A. Ghareeb; Aliaa Masoud; Marwa F. Harras; Mohamed El-Atawy; Nuha Salamah Alharbi; Magda M. F. Ismail
• Keywords: 0301 basic medicine; Chemistry; 03 medical and health sciences

The EGFR/PI3K/Akt/mTOR pathway is important for metastasis, medication resistance, apoptosis prevention, and malignant transformation.