Regioselective cyclocondensations with thiobarbituric acid: spirocyclic and azocine products, X-ray characterization, and antioxidant evaluation

• DOI: 10.1039/d4ra07966c
• Publication Date: 2025-03-19T12:33:12Z
• Authors: Efraín Polo-Cuadrado; Karen Acosta-Quiroga; Cristian Rojas-Peña; Yeray A. Rodrigue...; Edgard Fabián Bla...; Jhon J. Lopez; Iván Brito; Jonathan Cisterna; Joel B. Alderete; Margarita Gutiérrez

Multicomponent cyclocondensations of 5-amino-3-methyl-1-phenyl-1H-pyrazole (AMPZ), thiobarbituric acid, and p-formaldehyde under conventional thermal heating or ultrasonic irradiation were studied.