C–H functionalization of 2-alkyl tryptamines: direct assembly of azepino[4,5-b]indoles and total synthesis of ngouniensines

• DOI: 10.1039/d4sc02802c
• Publication Date: 2024-07-05T16:21:08Z
• Authors: Kejing Xie; Zeyuan Shen; Peng Cheng; Haoxiang Dong; Zhi-Xiang Yu; Liansuo Zu
• Keywords: Chemistry; 01 natural sciences; 0104 chemical sciences

The concise total synthesis of ngouniensines is reported, in which 2-Me-tryptamine undergoes sequential C–H functionalization with different aldehydes to afford the azepino[4,5-b]indole core and an exocyclic conjugated alkene, respectively.