Enhancing the antibacterial efficacy of vancomycin analogues: targeting metallo-β-lactamases and cell wall biosynthesis

• DOI: 10.1039/d4sc03577a
• Publication Date: 2024-09-09T07:21:12Z
• Authors: Paramita Sarkar; Weipan Xu; Melissa Vázquez-H...; Geetika Dhanda; Shubhandra Tripathi; Debajyoti Basak; Hexin Xie; Lea Schipp; Pascal Dietze; Julia E. Bandow; Nishanth N. Nair; Jayanta Haldar

A two-in-one vancomycin derivative that acts through multiple mechanisms to inhibit drug-resistant Gram-positive bacteria and resensitizes critical priority Gram-negative pathogens to carbapenems.