Engineering lauric acid-based nanodrug delivery systems for restoring chemosensitivity and improving biocompatibility of 5-FU and OxPt against Fn-associated colorectal tumor

• DOI: 10.1039/d4tb00103f
• Publication Date: 2024-03-23T02:20:55Z
• Authors: Meihui Su; Xin Wen; Yunjian Yu; Na Li; Xiaohui Li; Xiongwei Qu; Mahmoud Elsabahy; Hui Gao
• Keywords: 0301 basic medicine; 03 medical and health sciences

The tailored nanomedicine 5-FU-LA@PPL could selectively combat Fn, inhibit autophagy in CRC cells, restore chemosensitivity of 5-FU as well as OxPt, and consequently enhance the combination chemotherapy effects for Fn-associated drug-resistant CRC.