Illuminating apoptosis: a visible light-activated chloride carrier for chloride transport and cell death

• DOI: 10.1039/d4tb02436b
• Publication Date: 2025-04-02T12:21:22Z
• Authors: Manzoor Ahmad; Naveen J. Roy; Debashis Mondal; Thangavel Vijayak...; Mayurika Lahiri; Pinaki Talukdar
• Keywords: Visible spectrum

Synthetic chloride carriers are known to induce chloride-mediated apoptosis inside cancer cells. One of the main disadvantages is unfavorable cytotoxicity towards healthy cells due lack selectivity. The use stimuli, such as light, enzymes, ligands, etc., has enabled selective activation these systems in Light, notably, a significant stimulus that been utilized its excellent spatiotemporal control, remote addressability, and low cytotoxicity. However, previously reported photoresponsive require UV radiation for their activation, which tissue penetration can lead phototoxic cell damage or death. Herein, we report 3-substituted indole-2-carboxamide ion o-nitrobenzyl (ONB) linked procarriers. incorporation electron-donating substituents ONB photocleavable group leads red shift absorption wavelength, N,N-dimethyl-based procarrier, absorbance peak extends up 500 nm. Eventually, all synthesized procarriers were photoactivated MCF-7 under 400 nm electromagnetic radiation, procarrier was also at 450 This photoactivation higher wavelength highly desirable practical biological applications.