Increase of Total Body Potassium and Decrease of Exchangeable Sodium after Long-Term Treatment with a β-Receptor-Blocking Agent (Prindolol) in Essential Hypertension

• DOI: 10.1042/cs051551s
• Publication Date: 2015-08-07T06:31:32Z
• Authors: H. M. Brecht; E. Werner; W. Schoeppe
• Keywords: Essential hypertension; Plasma renin activity; Basal (medicine)

1. The effect of long-term treatment with prindolol on blood pressure, total body potassium (Kt), exchangeable sodium (Nae) and plasma renin activity was investigated in twelve patients essential hypertension. 2. Systolic diastolic pressures were significantly reduced from 164/112 to 127/90 mmHg under basal conditions. 3. Before Na. hypertension higher than normotensive individuals. After an average 16 weeks Nae decreased, despite increase weight 2 kg the patients. 4. In contrast decrease Nae, Kt found be increased after prindolol. values before prindolol, however, did not differ corresponding sex- age-dependent normal values. 5. Plasma slightly diminished orthostatic conditions; stimulatory orthostasis abolished but by 6. It is suggested that changes balance contribute anti-hypertensive