Effect of Vitamin D Deficiency on Sarcoplasmic Reticulum Function and Troponin C Concentration of Rabbit Skeletal Muscle

• DOI: 10.1042/cs0570257
• Publication Date: 2015-08-07T10:36:07Z
• Authors: Jennifer J. Pointon; M. J. O. Francis; R. Smith
• Keywords: Weanling; Troponin C

1. Weanling rabbits were made rachitic either by a vitamin D-deficient diet or parenteral administration of ethane 1-hydroxy-1,1-diphosphonate (EHDP) in amounts sufficient other species to block the formation 1,25-dihydroxycholecalciferol [1,25-(OH)2D3]. 2. The uptake calcium into isolated sarcoplasmic reticulum from mixed striated quadriceps muscle, and amount troponin C (the calcium-binding component complex) relation proteins same measured. 3. In muscle animals dietary deficiency D, rate concentration both significantly less (P than 0.02) control littermates. EHDP-treated no significant differences controls found. 4. These results show that D such can affect physiology. Since changes are found with EHDP, who presumably have selective 1,25-(OH)2D3, it is possible effect on mediated through metabolites 1,25-(OH)2D3 as 25-hydroxycholecalciferol.