Effect of hyperglycaemia on glucose concentration of human nasal secretions

• DOI: 10.1042/cs20030333
• Publication Date: 2004-04-26T15:19:13Z
• Authors: David M. WOOD; Amanda L. BRENNAN; Barbara J. PHILIPS; Emma H. BAKER
• Keywords: Glucose oxidase; Carbohydrate Metabolism

Glucose is not detectable in airways secretions of normoglycaemic volunteers, but present at 1-9 mmol x l(-1) from people with hyperglycaemia. These observations suggest the existence a blood glucose threshold which appears secretions, similar to that seen renal and salivary epithelia. In study we determined nasal secretions. Blood concentrations were raised healthy human volunteers by 20% dextrose intravenous infusion or 75 g oral load. Nasal measured using modified oxidase sticks as raised. appeared rapidly once was clamped approx. 12 ( n =6). On removal clamp, fell baseline levels parallel concentrations. An airway 6.7-9.7 identified =12). six subjects normal tolerance, rose above became following an The presence suggests active transport epithelial cells normally maintains low exceeds after load even so it likely diabetes hyperglycaemia spend significant proportion each day their