Lung function and respiratory symptoms in a randomized smoking cessation trial of electronic cigarettes

• DOI: 10.1042/cs20160268
• Publication Date: 2016-08-20T02:19:07Z
• Authors: Fabio Cibella; Davide Campagna; Pasquale Caponnetto; Maria Domenica Am...; Massimo Caruso; Cristina Russo; Donald W. Cockcroft; Riccardo Polosa
• Keywords: Adult; Male; Adolescent; electronic cigarettes; respiratory function tests; respiratory symptoms; smoking cessation; tobacco harm reduction; Respiration; Smoking; Respiratory function tests; Smoking cessation; Electronic Nicotine Delivery Systems; Middle Aged; 3. Good health; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Electronic cigarettes; Tobacco harm reduction; Humans; Female; Smoking Cessation; Respiratory symptoms; Prospective Studies; Lung; Aged

Quitting smoking is the most important step smokers can take to improve their health. Nonetheless, there little information on long-term improvements in lung function and/or respiratory symptoms after cessation. Here we illustrate changes spirometric indices as well invited quit or reduce cigarette consumption by switching electronic cigarettes (ECs). Prospective evaluation of consumption, spirometry and was performed a 1-year randomized controlled trial receiving EC containing 2.4%, 1.8% 0% nicotine. Spirometric data are presented basis participants' pooled continuous phenotype classification (Quitters, Reducers, Failures), whereas point prevalence-smoking phenotype. Smoking Failures) had no significant effect (FEV1, FVC FEV1/FVC) with exception FEF25-75%, which significantly (P =0.034) increased over time among Quitters; FEF25-75% (% predicted) improving from (means±S.D.) 85.7±15.6% at baseline (BL) 100.8±14.6%. High prevalence cough/phlegm (43.1%) shortness breath (SoB; 34.8%) reported BL substantial reduction frequency subsequent follow-up visits. These virtually disappeared very quickly both quitters reducers. Smokers switch ECs who completely abstained showed steady progressive Normalization peripheral airways associated improvement symptoms, adding notion that abstaining reverse tobacco harm lung.