Repetitive schistosoma exposure causes perivascular lung fibrosis and persistent pulmonary hypertension

• DOI: 10.1042/cs20220642
• Publication Date: 2023-04-04T17:53:48Z
• Authors: Rahul Kumar; Michael H. Lee; Biruk Kassa; Dara C. Fonseca B...; Claudia Mickael; Linda Sanders; Adam Andruska; Maya Kumar; Edda Spiekerkoetter; Angela Bandeira; Kurt R. Stenmark; Rubin M. Tuder; Brian B Graham
• Keywords: Schistosoma; Intraperitoneal injection

Abstract Background: Pulmonary hypertension (PH) can occur as a complication of schistosomiasis. In humans, schistosomiasis-PH persists despite antihelminthic therapy and parasite eradication. We hypothesized that persistent disease arises consequence exposure repetition. Methods: Following intraperitoneal sensitization, mice were experimentally exposed to Schistosoma eggs by intravenous injection, either once or three times repeatedly. The phenotype was characterized right heart catheterization tissue analysis. Results: single egg resulted in PH peaked at 7–14 days, followed spontaneous resolution. Three sequential exposures phenotype. Inflammatory cytokines not significantly different between one doses, but there an increase perivascular fibrosis those who received doses. Significant also observed autopsy specimens from patients died this condition. Conclusions: Repeatedly exposing schistosomiasis causes phenotype, accompanied fibrosis. Perivascular may contribute the humans with disease.