Doublecortin expression in the adult rat telencephalon

• DOI: 10.1046/j.0953-816x.2001.01683.x
• Publication Date: 2003-03-06T14:42:03Z
• Authors: Juan Nacher; Carlos Crespo; Bruce S. McEwen
• Keywords: Doublecortin; Piriform cortex; Rostral migratory stream; Neuroblast; Granule cell; Synaptogenesis; Anterior olfactory nucleus

Abstract Doublecortin (DCX) is a protein required for normal neuronal migration in the developing cerebral cortex, where it widely expressed both radially and tangentially migrating neuroblasts. Moreover, has been observed adult rostral migratory stream, which contains precursors traveling to olfactory bulb. We have performed DCX immunocytochemistry rat brain identify precisely populations expressing this protein. Our observations confirm presence of immunoreactive cells with characteristic morphology neuroblasts subventricular zone, stream main accessory bulbs. also found putative regions were no described, as corpus callosum, piriform cortex layer III/endopiriform nucleus striatum. Surprisingly, many phenotype differentiated neurons immunoreactive; e.g. certain granule hilar border granular dentate gyrus, some types II, periglomerular bulbs, isolated Almost all express polysialylated form neural cell adhesion molecule similar distribution collapsin receptor‐mediated protein‐4, two molecules involved structural plasticity. Given these results, we hypothesize that expression could be related its capacity microtubule reorganization fact linked axonal outgrowth or synaptogenesis.